Arsenal manager Mikel Arteta continues rebuilding the side around goal machine Pierre-Emerick Aubameyang and younger talents like Bukayo Saka.
Here is a look at the clubs most likely to give City a run for their money next season.
Manchester City edged past Arsenal and Liverpool beat Chelsea to reach the League Cup semi-finals Tuesday while Cardiff City also made the last four on an emotional night in south Wales.
Former Arsenal, Spain midfielder Fabregas hangs up his boots, to coach Italian club.
IMAGES from the EPL matches played on Tuesday
Manchester United manager Alex Ferguson stuck the boot into Manchester City ahead of their derby clash at Old Trafford on Sunday by insisting that Liverpool will always be United's biggest rivals.
'I've been here 20 years and many times had the opportunity to leave. I don't have to convince you my preference has always been Arsenal'
Arsenal thrashed Middlesbrough 7-0, while Manchester United lost 3-1 at Manchester City in the Premier League.
Arsenal will not sell striker Olivier Giroud, midfielder Jack Wilshere and winger Theo Walcott in the January transfer window despite their lack of playing time at the Premier League club, manager Arsene Wenger has said.
Van Dijk was substituted early in the game when Everton goalkeeper Jordan Pickford made a reckless challenge in the box, which left Liverpool manager Juergen Klopp fuming.
An opening-day Premier League defeat, a growing injury list and the weight of an unspent transfer kitty hang heavily over Arsenal as they head into Wednesday's Champions League playoff clash with Fenerbahce.
Real Madrid earned their first-ever win over Liverpool with a wondrous Cristiano Ronaldo goal spearheading a 3-0 Champions League victory at Anfield on Wednesday which appeared as classy as it was dominant.
Pepe Reina produced three excellent saves to help lethargic Liverpool earn a point from a goalless and somewhat predictable Premier League draw at Birmingham City on Sunday.
City open the season on Aug. 11, with the final round of matches scheduled for May 19, 2024.
Holders Manchester City beat Chelsea 1-0 with a late Bernardo Silva goal on Saturday to reach the FA Cup final after an absorbing end-to-end Wembley semi-final left the exhausted winners still chasing a domestic double.
League leaders Chelsea and Liverpool however won their matches in the Premier League.
Antonio Valencia's early thunderbolt put Manchester United en route to a 4-0 Premier League victory over Everton on Sunday, but they needed a flurry of late goals to finally subdue their unfortunate visitors.
Aaron Ramsey indulged his new goalscoring habit on his return to his boyhood club as Arsenal opened up a seven-point lead at the top of the Premier League with a 3-0 victory at Cardiff City on Saturday.
UEFA president Lennart Johansson supports the principle that a club winning the Champions League must be allowed to defend their title.
Michael Owen has stuck the boot into Arsenal's Premier League title credentials and claims record signing Mesut Ozil is too inconsistent to lead the Gunners to glory, according to reports.
Manager Juergen Klopp's leadership is laying the foundations for "something special" at Liverpool, forward Giorginio Wijnaldum has said. Liverpool have started the new Premier League campaign with 10 points from a possible 15 after a 2-1 victory over Chelsea at Stamford Bridge on Friday. The Merseyside club, who won at Arsenal and also beat champions Leicester City 4-1, were held to a 1-1 draw by Tottenham Hotspur at White Hart Lane following their 2-0 defeat by promoted Burnley last month.
Juergen Klopp returns to the scene of one his Liverpool side's most controversial victories of last season this Saturday with the man who fashioned it lining up against him.
Arsenal's Andrei Arshavin scored four goals in a pulsating 4-4 draw at Anfield on Tuesday to put a huge dent in Liverpool's Premier League title push.
Chelsea need to improve a lot before they could be considered Premier League title contenders, manager Antonio Conte has said after his resurgent side beat Southampton 2-0 on Sunday.
The striker picked up a hamstring injury in Tuesday's Champions League quarter-final 2-1 defeat by Chelsea.
Thierry Henry scored with a brilliant individual effort to give the English side a 1-0 victory in the first leg last 16 knock-out round.
Images from Saturday's action in the English Premier League.
Klopp and his City counterpart Pep Guardiola were satisfied with their team's displays in a tight, tactical encounter which finished 0-0 at Anfield, but the German was clearly frustrated to now lose his players for international duty.
Lukas Podolski and Olivier Giroud gave food for thought to Arsenal fans craving a new striker by scoring in a 3-1 Premier League win at Fulham on Saturday while Liverpool made it two victories from two games at Aston Villa.
Arsenal manager Arsene Wenger said he is still keen to sign Uruguayan striker Luis Suarez even though Liverpool have rejected two offers from the Gunners for him.
Champions Liverpool were sent crashing out by Benfica.
Chelsea lost their 100 per cent Premier League record when London rivals West Ham United held them to a 0-0 draw on Sunday.
Chelsea brought a whole new dimension to the Premier League title race when they handed Manchester City their first defeat of the season on Saturday to leave Mohamed Salah-inspired Liverpool as the new leaders.
Arsenal goalkeeper Petr Cech believes that the Gunners need to stop silly losses against the teams they are expected to beat if they want to progress in the Premier League.
Arsenal delivered a brutal lesson in fast-paced Premier League football to beat Liverpool 4-1 on Saturday, maintaining their faint title aspirations and almost certainly dashing their opponents' hopes of a top-four finish.
Liverpool went top of the Premier League on Monday after a goalless home draw with West Ham United.
Such is the impact Sadio Mane has made on Liverpool that the 24-year-old is an automatic pick to face Tottenham Hotspur in the Premier League on Saturday while experienced international teammates scrap it out to play alongside him.
Arsene Wenger acknowledged Southampton were the sharper team as they crushed Arsenal 4-0 on Saturday but he also blamed the defeat on bad luck.
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